Genomic Imprinting: Mechanisms, Significance and Evolution
نویسندگان
چکیده
منابع مشابه
Mechanisms of genomic imprinting.
Imprinted genes represent a curious defiance of normal Mendelian genetics. Mammals inherit two complete sets of chromosomes, one from the mother and one from the father, and most autosomal genes will be expressed from both the maternal and the paternal alleles. Imprinted genes, however, are expressed from only one chromosome, in a parent-of-origin-dependent manner. Because silent and active pro...
متن کاملThe evolution of genomic imprinting.
In some mammalian genes, the paternally and maternally derived alleles are expressed differently: this phenomenon is called genomic imprinting. Here we study the evolution of imprinting using multivariate quantitative genetic models to examine the feasibility of the genetic conflict hypothesis. This hypothesis explains the observed imprinting patterns as an evolutionary outcome of the conflict ...
متن کاملThe evolution of genomic imprinting.
We explore three possible pathways for the evolution of genomic imprinting. (1) Imprinting may be advantageous in itself when imprinted and unimprinted alleles of a locus confer different phenotypes. If a segment of DNA is imprinted in the gametes of one sex but not in those of the other, it might lead to effects correlated with sexual dimorphism. More fundamentally, in certain organisms, sex d...
متن کاملGenomic imprinting, maternal care, and brain evolution.
The majority of autosomal genes are inherited as two copies, one from each parent, and such biallelically inherited genes have identical functions. Genomic imprinting confers different functions on the two parental genomes during development by silencing one allele of each imprinted gene in a parent-oforigin-dependent manner. Hence imprinted genes usually function when inherited either from the...
متن کاملThe evolution of X-linked genomic imprinting.
We develop a quantitative genetic model to investigate the evolution of X-imprinting. The model compares two forces that select for X-imprinting: genomic conflict caused by polygamy and sex-specific selection. Genomic conflict can only explain small reductions in maternal X gene expression and cannot explain silencing of the maternal X. In contrast, sex-specific selection can cause extreme diff...
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ژورنال
عنوان ژورنال: Journal of Mammalian Ova Research
سال: 2003
ISSN: 1341-7738,1347-5878
DOI: 10.1274/jmor.20.64